NSF Calls for Examinations of Emergent Networks as Part of Understanding the Rules of Life “Big Idea”

Nicolle Rager Fuller, National Science Foundation

The biological world is interconnected by complex networks. What are the rules that control these networks? How are the interactions altered by environments? Are the rules similar across all biological scales? How can an understanding of such roles be harnessed to benefit society?

The new Understanding the Rules of Life: Emergent Networks (URoL:EN) solicitation encourages convergent, cross-disciplinary research – including the biological sciences – to examine such rules, the outcomes of these interactions, and to aid in the prediction of emergent properties. The program also seeks to train STEM practitioners to contribute to this area of convergent research. Proposals under the solicitation should be submitted by May 10, 2021.

As part of the Understanding the Rules of Life: Predicting Phenotype, one of ten “Big Ideas” NSF-wide, this new solicitation builds on previous URoL programs to help increase knowledge and the ability to predict an organism’s observable characteristics—its phenotype—from its genotype.

Understanding the mechanisms at play in the interconnections between living organisms and their environments, across every biological scale, will provide vital insight into grand biological challenges, help advance biotechnology to spur the US bioeconomy, and aid in solving some of society’s issues, including the growing impacts of infectious disease and climate change.

Investigators from across the biological sciences are encouraged to submit proposals in concert with researchers in other disciplines, including the mathematical and physical sciences, geosciences, computer and information sciences, engineering, and behavioral and social sciences.

Directorates from across NSF will be holding a virtual office hour on March 11 beginning at 2:00pm Eastern to answer questions on the solicitation. Register in advance for this webinar: https://nsf.zoomgov.com/webinar/register/WN_kP23L5ymTFKw5EVCqBFcCQ.

For full details and guidance on award types, amounts and other questions, see Understanding the Rules of Life: Emergent Networks (URoL:EN).

NSF Announces Call for Center for Advancement and Synthesis of Open Environmental Data and Sciences

NSF has released a new solicitation for a Center for Advancement and Synthesis of Open Environmental Data and Sciences (NSF 21-549). Letters of Intent for the solicitation are due on April 1, 2021

Exemplifying open and team science, the Center will be fueled by open and freely available biological and other environmental data to catalyze novel scientific questions in environmental biology through the use of data-intensive approaches, research networks, and training in the accession, management, analysis, visualization, and synthesis of large data sets.

The Center will provide vision for speeding discovery through the increased use of large, publicly accessible datasets – such as those provided by the National Ecological Observatory Network (NEON), Integrated Digitized Biocollections (iDigBio), the LTER network, Global Biodiversity Information Facility (GBIF), and others – to address biological research questions through collaborations with scientists in other related disciplines, as well as key questions that emerge at interfaces between biology, informatics, and a breadth of environmental sciences.

It also will foster the development of generalizable cyberinfrastructure solutions and community-driven standards for software, data, and metadata that support open and team science, and role-modeling best practices.

The Center will be a leader in diversifying the data-intensive environmental science workforce across demographic, geographic, institutional, and disciplinary dimensions and will further enable data-driven discovery through immersive education and training experiences to provide the advanced skills needed to maximize the scientific potential of large volumes of available open data.

For more information on the solicitation, including a list of cognizant Program Officers, please visit the program page: https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=505829&org=NSF&sel_org=NSF&from=fund.

From the AD: BIO “No-Deadline” Solicitations Migrating to Research.gov

As part of NSF’s ongoing efforts to innovate and migrate proposal preparation and submission capabilities from FastLane to Research.gov (see Important Notice No. 147), the Directorate for Biological Sciences (BIO) has announced that proposal submissions for our “no-deadline” programs will migrate to Research.gov beginning with revised solicitations to be released in the near future. This change was announced in a Dear Colleague Letter (NSF 20-129) released today and is the first phase of a migration of all NSF solicitations to Research.gov.

Specifically, the following programs will have new solicitations published in the coming weeks at which point investigators should begin submitting proposals through Research.gov. There will be a grace period of 90-days from the date on which the new solicitations are published during which proposals can still be submitted through FastLane. After the 90-day period, the new solicitations will no longer be available in FastLane and any new proposals must be submitted through Research.Gov (or Grants.Gov).

The programs whose solicitations will migrate from FastLane to Research.gov are:

Research.gov improves the user experience while also reducing administrative burden. The system is also flexible enough to meet both users’ changing needs and emerging government requirements. A significant fraction of proposals is already being submitted through Research.gov and investigators report it to be intuitive to use. We do not anticipate that the change to Research.gov will have significant impacts on the submission process. This migration will not affect the merit review process in any way.

To support the community through this migration, technical support and FAQs and videos on proposal submission through Research.gov are available. In addition, we are offering a series of BIO-wide virtual office hours during which you can ask questions of BIO Program Officers.

The virtual office hours will occur on Monday, October 19 at 11 a.m. EDT; Tuesday October 20 at 10 a.m. EDT; Wednesday, October 21 at 1 p.m. EDT; and Thursday, October 22 at 3 p.m. EDT. Members of the community can register for these sessions via NSF.gov.

Finally, if you have any immediate questions please reach out to BIOnodeadline@nsf.gov, which is monitored by Program Officers from across BIO.

Sincerely,

Image of the signature of Dr. Joanne Tornow, Assistant Director for Biological Sciences

Joanne S. Tornow, Ph.D.

Assistant Director

From The AD: New Funding Opportunities for Understanding the Rules of Life

Image of the world with "NSF" lettering in white.

Dear Colleagues,

BIO is excited to announce to the biological sciences community two new funding opportunities under the Understanding the Rules of Life (URoL) Big Idea: 1) Epigenetics and 2) Microbiome Theory and Mechanisms (MTM). The URoL Big Idea seeks to create a new paradigm at the convergence of science, engineering, and technology that will elucidate theoretical frameworks (rules) to enable prediction of the diversity of evolutionary solutions that biological systems use to support life processes seen across the planet. The National Science Foundation has recently invested $36 million in the first projects under the URoL portfolio from two separate solicitations and across more than thirty institutions.

The Epigenetics and MTM opportunities represent a collaboration across Directorates and Offices within the National Science Foundation. Specifically, Epigenetics intends to enable innovative research and promote multidisciplinary education and workforce training in the broad area of epigenetics, while MTM aims to understand and establish theory and mechanisms that govern the structure and function of microbiomes.

Integrative perspectives and research approaches from more than one research discipline are welcomed, as this is a cross-Directorate effort. The interdisciplinary scope of both programs aims to provide unique training and outreach opportunities to train the next generation of scientists in a diversity of scientific approaches and to engage society more generally.

Both programs offer two submission tracks:

  • Track 1 – for projects with a total budget of up to $500,000 and an award duration of up to 3 years, and
  • Track 2 – for projects with a total budget of up to $3,000,000 and award duration of up to 5 years.

For complete details on deadlines and submission guidelines, refer to the Epigenetics program website or contact the Epigenetics Team (epigen@nsf.gov), and the MTM program website or the MTM Team (microbiome@nsf.gov).

BIO looks forward to continuing working on this cross-Directorate venture.

Sincerely,
Image of the signature of Dr. Joanne Tornow, Assistant Director for Biological Sciences
Joanne Tornow, PhD
Assistant Director for Biological Sciences

New BIO Funding Opportunity for the Reintegration of Biology

Supporting fundamental biological research that takes an integrative approach to understanding life’s key innovations is a priority for the BIO Directorate. Despite biology’s unifying goal of understanding the processes that generate and sustain life, the actual practice of modern biology has become increasingly fragmented into subdisciplines due, in part, to specialized approaches required for deep study of narrowly defined problems.

BIO now aims to strengthen the connections between biological subdisciplines and encourage a reintegration of biology through a new funding opportunity: Biology Integration Institutes. Letters of Intent are due on December 20, 2019 and full proposals are due on February 6, 2020.

The Biology Integration Institutes will support collaborative teams of researchers at a level not feasible in most existing core programs and over a more extended timeframe than is typical of standard NSF awards. Our goal is to stimulate creative integration of diverse biological disciplines using innovative experimental, theoretical, and computational approaches to discover underlying principles operating across all levels of life, from biomolecules to organisms, species, ecosystems, and biomes. While this solicitation focuses on the integration of biological disciplines, any field beyond biology may be included as needed to address the overarching biological theme.

We also intend for the Institutes to enable research and training in a truly integrated environment, preparing the next generation of biological scientists to pursue discipline-spanning research throughout their careers. In these ways, the Biology Integration Institutes will enable the workforce and innovations that will inspire new applications to drive our bioeconomy and provide solutions to pressing societal challenges.

Proposals may be submitted in one of two tracks. Implementation proposals are for teams that have already developed an Integrative Research Plan around a theme of significance, designed an educational approach that employs effective methods for depth and breadth of training, and prepared a cohesive and sustainable Management Plan that is ready for deployment. Design proposals are for teams to develop communities and groundbreaking ideas to be submitted to later competitions as Implementation proposals through diverse and sustained activities, including workshops and follow-up meetings.

This funding opportunity is a part of BIO’s larger efforts to stimulate integrative thinking in the biological research community. To learn more about the Biology Integration Institutes, visit the solicitation and program website, or reach out to the cognizant program directors:

Shape the Future of Synthetic Biology! Apply for Funding to Mentor High School iGEM Teams

NSF is calling for requests for supplements and proposals to support high school teams participating in the International Genetically Engineered Machine – or “iGEM” – competition.

Attracting diverse students to STEM careers at a young age is essential to ensure the realization of a vibrant U.S. bioeconomy that will fuel innovation, economic growth and job creation. Synthetic biology has emerged as a major driver of innovation and technological advancement; as such, active researcher engagement of young people in synthetic biology is an important early step in workforce development to support a growing bioeconomy.

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Participants in the 2018 iGEM Giant Jamboree.
Image credit: iGEM Foundation, Justin Knight.

iGEM has emerged as the premier opportunity to engage students in creative research and technology development projects in synthetic biology. Annually, over 6,000 students from around the world at the high school, undergraduate, and master’s level participate in iGEM, working to design, build and test creative solutions to societal challenges using the tools of synthetic biology.

To support early career workforce development in this growing field, NSF is encouraging principal investigators of existing NSF awards to apply for supplements through the Research Assistantships for High School Students (RAHSS) mechanism to support iGEM teams. Supplements can vary in size but are expected to average approximately $10,000 per team. Additionally, NSF encourages the submission of Research Coordination Networks (RCN) proposals that would support dissemination of best practices for working with high school iGEM teams, and/or ways of remote mentoring of teams that are not located near a research university with synthetic biology capabilities. RCN proposals can be submitted at any time to the Biological Sciences or Engineering Directorates.

For more information on iGEM and how researchers can participate, visit iGEM.org.

NEON Webinar

Learn about the upcoming NEON Webinar from our colleagues in the Division for Biological Infrastructure here or below.

The National Science Foundation (NSF) recently announced its intention to carry out a competition to manage the Operations and Maintenance of the National Ecological Observatory Network (NEON). The Dear Colleague Letter (NSF 19-080) announcing this decision:

  • provides general information on NEON,
  • communicates that NSF anticipates initiating the competition,
  • provides information on provisional goals,
  • outlines a timeline for the competition, and
  • invites comments and questions from eligible organizations interested in this competition (submit via neon-bot@nsf.gov).

NSF will be hosting a webinar on September 11th at 2pm regarding the planned competition for operation and management of NEON. Individuals, teams, and organizations interested in submitting proposals should try to participate.

This webinar will discuss the timeline for executing the competition for the management of NEON Operations and Maintenance. It will highlight key decision points by NSF and identify critical dates for activities related to the competition. The webinar will also provide information on the post-award oversight requirements for awards managed through cooperative agreements (CAs). Following the presentation, there will be a question and answer period.

For further details about the competition, please consult the NEON Program webpage and DCL (NSF 19-080).

For more details about NEON, please consult the NEON Project webpage.

NEXT STEPS for NEON

One of BIO’s highlights from this current fiscal year is the movement of the National Ecological Observatory Network (NEON) from construction into full operations. 179 data products are now freely available to the scientific community and the public on the NEON Data Portal, and we are pleased to note that downloads of the data are rapidly increasing as is use of NEON data in publications. NEON data is also transforming ecological education at a diverse range of institutions.

NSF recently announced (NSF 19-080) its intent to launch an open competition for the management of NEON’s future operations and maintenance. NSF’s major facilities routinely undergo such a merit-based, peer-reviewed process, thus the announcement signals that NEON has matured into a fully-functioning Observatory.  The review process will take roughly two years, with the new award expected to commence in late 2021.  As always, NSF will be relying on community expertise in the merit review process, which will ensure that NEON is an effective resource for ecology for years to come.

We recognize that members of the scientific community may have questions and input for NSF as we embark on this process. We welcome community input, and to that end, we will host a NEON Information Session and Question and Answer Period on Monday, August 12, at the Ecological Society of America’s Annual meeting in Louisville, KY. For those who won’t be at ESA, questions and input can be directed to the cognizant program officer, Dr. Roland Roberts (neon-bot@nsf.gov).

We hope to see many of you at ESA.

AccelNet Webinar Next Monday, 11/5

Accelerating Research through International Network-to-Network Collaborations (AccelNet) supports strategic linkages among U.S. research networks and complementary networks abroad that will leverage research and educational resources to tackle grand scientific challenges that require significant coordinated international efforts.  AccelNet invites proposals, submitted by U.S.-based researchers, for the creation of international networks of networks in research areas aligned either with one of the NSF Big Ideas or a community-identified challenge with international dimensions.

For the first competition, Letters of Intent for are due December 21, 2018 and Full Proposals due February 28, 2019.  The NSF Office of International Science and Engineering (OISE) funded several workshops that will take place in 2019, and we will offer webinars for the community.

The first webinar will be this Monday, November 5 – visit the event page for webcast info. Updates on future webinars will be posted on the program page.

Additional information on this program is available on the AccelNet Program Page. We invite you to direct any questions to oise-accelnet@nsf.gov.

New DCL Seeks to Discover the Rules of Life

Care Of New Life - Baby Plant
Image: Romolo Tavan

In 2016, NSF Director France Córdova unveiled ten “Big Ideas” to shape NSF’s priorities for investment at the frontiers of science and engineering, and drive American science into the future. One in particular – “Understanding the Rules of Life” – has reshaped how we at the BIO Directorate think about scientific inquiry in the biological sciences. The Rules of Life Big Idea seeks discoveries that will allow us to accurately predict change and outcomes in biological systems, and to develop infrastructure and innovative tools to help us ask more complex questions than ever before.

NSF has now published a Dear Colleague Letter (“DCL”; NSF 18-031) catalyzed by this Big Idea, titled, “Rules of Life: Forecasting and Emergence in Living Systems.” This DCL solicits research proposals to develop a better understanding of complex interactions within biological systems, and identify causal, predictive relationships across scales, levels of organization and layers of complexity – so-called “rules” for how life functions.

This DCL describes an initial opportunity to identify areas where such rules may exist, to drive progress toward their discovery, and to focus efforts on using these rules for prediction and design of biological systems. Activities supported through this DCL include conferences, EArly-concept Grants for Exploratory Research (EAGERs) and Research Advanced by Interdisciplinary Science and Engineering (RAISE) grants to create opportunities for enabling predictive capability.

The knowledge, infrastructure and human capital that will be needed to successfully address such complex questions and identify Rules of Life will require convergence of research across many disciplines. As a result, Directorates across NSF are participating in this DCL, including BIO, Computer and Information Science and Engineering (CISE), Education and Human Resources (EHR), Engineering (ENG), Geosciences (GEO), Mathematical and Physical Sciences (MPS) and Social, Behavioral and Economic Sciences (SBE). Interdisciplinary and collaborative research proposals are welcomed under this DCL.

Be sure to read the DCL and Proposal and Award Policies and Procedures Guide to find complete details about the Rules of Life, instructions for submission and all deadlines.

Questions? Comments? Feedback? Email RoLBIO@nsf.gov.