On January 10, 2018, Dr. Jim Olds’ term as Assistant Director for Biological Sciences came to an end. Since taking up the post in September 2014, Dr. Olds has led BIO through many big changes, including the conception of the Rules of Life Big Idea and implementation of a no-deadline submission mechanism for receiving and reviewing proposals. All of us at BIO would like to thank Dr. Olds for his excellent leadership over the past three and a half years, and wish him the best as he returns to George Mason University.
Dr. Joanne Tornow, Head of the Office of Information and Resource Management (OIRM) and former BIO Acting Deputy Assistant Director, will be taking up the mantle as Acting Assistant Director for BIO while the search for Dr. Olds’ successor is underway. Stay tuned to learn more about Dr. Tornow and the exciting things she has planned for the directorate in the coming months!
On November 8, 2016, the NSF’s Assistant Director for Biological Sciences, Dr. Jim Olds, presented to the National Science Board an overview of the BIO Directorate’s research and infrastructure investments. This is a brief summary of his major talking points.
The NSF provides approximately 68 percent of federal support for basic research in biological sciences (not including support from the National Institutes of Health).
NSF Support of Academic Basic Research in Selected Fields as a Percentage of Total Federal Support. “Biology” includes biological sciences and environmental biology; excludes NIH. Source: NSF/NCSES FY2014
One of the ways in which NSF ensures that basic biology achieves downstream impacts is through partnerships with other agencies, in the U.S. and internationally, and public-private partnerships; for example, with the USDA, NIH, BBSRC, Bill and Melinda Gates Foundation and others.
The research supported by BIO’s Divisions crosses scales of size, space, time, and complexity.
The total FY2017 budget request for BIO is $791 million, which is about 1/10th of the NSF’s total request.
Part of the FY2017 budget request includes funds to support research across the Directorate related to the “Rules of Life” framing device which includes, but is not limited to, research focused on: the relationship between genes, the environment, and phenotype; plant and microbial sciences (microbiomes); synthetic biology; the origins of life; as well as support for quantitative, interdisciplinary approaches and resources for training and early career science. Support for projects that involve sophisticated modeling and theory development are seen as opportunities for partnerships with other NSF Directorates.
BIO’s “Rules of Life” framing device contributed to the development of the Ten Big Ideas for Future NSF Investments, specifically the “Predicting Phenotype” research challenge. Among the biggest gaps in our biological knowledge is how to predict the phenotype of a cell or organism from what we know about the genome and environment. The traits of an organism are emergent properties of multiple types of information process across multiple scales. Unpacking phenotypic complexity will require convergence across biology, computer science, mathematics, the physical sciences, behavioral sciences, and engineering.
More than a dozen initiatives constitute the “Major Investments” of BIO’s FY2017 request. Among these are Understanding the Brain, Clean Energy Technology, Microbiome, and support for training and education.
Using amazing new technologies, evolutionary neuroscientist Dr. Melina Hale and her graduate students at the University of Chicago are discovering that the basic movements of one tiny fish can teach us big ideas about how the brain’s circuitry works. Source: “Mysteries of the Brain,” produced by NBC Learn in partnership with the NSF (Full video: https://youtu.be/BUzeEpcO238)
“I love watching these cells be active while the animal is behaving. It’s just remarkable to me that we can see the brain work and try to understand how it’s functioning.” – PI Melina Hale
A new BIO program, Next Generation Network for Neuroscience (NeuroNex), will fund research with the goals of: developing theoretical frameworks for understanding brain function across organizational levels, scales of analysis, and/or a wider range of species; and the development and dissemination of innovative research resources, instrumentation and neurotechnology. We anticipate this portfolio will be transformative, integrative, and synergistic.
Support for clean energy technology-related research will involve funding for enhancing photosynthesis, for systems and synthetic biology, for bioinspired-design of proteins, for exploring the metabolic and energetic potential of living organisms, and for modeling environmental impacts, as well as impacts on genome stability, fitness, and phenotype.
In BIO’s FY2017 budget request, approximately $43 million is designated for programs that will enhance training and education, provide support for early career researchers, and broaden participation. BIO will continue participation in NSF INCLUDES, ADVANCE, CAREER, and Improving Undergraduate STEM Education. In addition, BIO will provide new opportunities for research traineeships (details to come!). It is also important to think about how we track students who are supported by BIO funding along their career trajectory and this will be a topic of discussion throughout the Directorate in 2017.
The Biological Science Directorate also recognizes how critical research resources (infrastructure), centers, observatories, networks, and support for data science are to the success of basic scientific research. CyVerse (was iPlant) integrates many aspects of data science, including providing key infrastructure for data management and analysis. This resource democratizes access to high-throughput computing. Continued investment in cyberinfrastructure would be congruent with some of the Ten Big Ideas for Future NSF Investments and would provide an avenue for BIO to continue to engage with partners in other NSF Directorates. The NSF recently announced awards for four new Science and Technology Centers – the Center for Cellular Construction is BIO-managed and will allow for the development and use of tools for controlling cell trajectories across the phenotypic landscape, which is important for understanding, for example, how cells become malignant.
The big picture for the future of the Directorate for Biological Sciences is this — biology is the engine of innovation in the 21st century. As President Obama said in his weekly address of October 16, 2016, “Innovation is in our DNA.”
In this Science Spotlight from the Kavli Foundation, a group comprising scientists and funders, including the NSF’s Assistant Director for Biological Sciences, Dr. Jim Olds, reflects on what the BRAIN Initiative has already achieved and how it is evolving.
On June 29, 2016, the Cancer Moonshot Summit was held on the campus of Howard University in Washington, DC. The National Science Foundation’s Assistant Director for the Directorate for Biological Sciences, Dr. Jim Olds, was pleased to represent the Foundation at the event.
From the Office of the Vice President of the United States:
“In his final State of the Union address, the President tasked the Vice President with heading up a new national effort, the Cancer Moonshot. The ultimate goal is to double the rate of progress—to make a decade’s worth of advances in cancer prevention, diagnosis, treatment and care in five years—to ultimately end cancer as we know it.
The goals of this effort cannot be achieved by one person, one organization, or one discipline. Solving the complexities of cancer will require the formation of new alliances to defy the bounds of innovation and accelerate the prevention, diagnosis, treatment, and—ultimately—a cure. It’s going to require millions of Americans speaking up and contributing what they’re able.
The Cancer Moonshot Summit will be a venue to bring together all sectors that have a role to play in making progress on the Cancer Moonshot goals to share new ideas and launch new collaborations and actions.
The Cancer Moonshot is a mission, and all of us #CanServe. How will you make a difference, break down barriers to progress, or catalyze change where you live or work?”
As transdisciplinary research becomes more mainstream, the National Science Foundation has supported this trend by creating new programs and unique funding streams to support collaborations and individual research that gets at the “sticky edges” between disciplines.
BioMaPS, or Research at the Interface of Biological, Mathematical and Physical Sciences, is an example of how a cross-Directorate initiative (involving BIO and the Directorates for Mathematical and Physical Sciences (MPS) and Engineering (ENG)), can be used to strategically invest in research on living systems across scales, from atoms, to organisms, to the environment.
The goals of BioMaPS involve discovering fundamental new knowledge at the intersections of biology, math, and physical sciences to better understand and replicate nature’s ability to network, communicate, and adapt and to enable innovation in national priorities such as clean energy, advanced manufacturing, and understanding the brain. For example, BioMaPS has and will accelerate the generation of bio-based materials and the advanced manufacturing of bio-inspired nanosensors, devices and platforms. Such investments are essential to the nation’s prosperity, economic competitiveness, and quality of life.
In fiscal years 2014 and 2015, NSF invested approximately $60 million total in BioMaPS-related research and plans to continue supporting this vital investment with the goal of attracting scientists and engineers to transdisciplinary research and educating the STEM workforce of tomorrow. For BIO, Emerging Frontiers has been providing matching funds to supplement the support of BioMaPS awards by established BIO programs.
Recently, BioMaPS FY15 funding was used to provide to Dr. Jennifer Doudna a Creativity Extension for her existing award, “Mechanisms of Acquired Immunity in Bacteria” (Division of Molecular and Cellular Biosciences). Dr. Doudna is a pioneer in studying Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs), whose function in bacteria is to recognize and destroy incoming phage or plasmid DNAs. CRISPR technology is now revolutionizing the biotech industry.
If you think your research meets the criteria of a BioMaPS project or you are considering developing a research project that reflects BioMaPS goals, please contact the Program Director for an established BIO program (i.e., there is not a separate solicitation or Dear Colleague Letter soliciting proposals specifically for BioMaPS funding).
This week, the Ecological Society of America (ESA) Centennial Meeting was held in Baltimore, Maryland, so I was able to visit and learn about some of the exciting research our NSF-funded students and PIs are doing in the field of ecology.
In the morning, I had an informative meet-and-greet session with a number of researchers who stopped by to chat with me about their research and their concerns and hopes regarding the future of biological science. We discussed the value of collaborative networks, of regional to continental scale data collection and access, of core funding through BIO’s Divisions, and a variety of other topics. Most important, I got to listen, ask questions, and learn from the scientific community. Though I am a neuroscientist, I am fascinated by and dedicated to absorbing as much information as I can about the fundamental science of the disciplines that are supported by the Directorate. As a young researcher and later as a mentor, I had the privilege of working at Woods Hole in Massachusetts, which fostered my appreciation for the dynamic nature of ecological studies and the challenges faced by researchers tasked with elucidating the interactions of organisms and their environments.
In the morning, I chatted with researchers from the University of Minnesota, UC Irvine, the University of Utah, and the Cary Institute of Ecosystem Studies.
In the afternoon, I attended the National Ecological Observatory Network (NEON) session which included many Ignite-style presentations about the data and resources that NEON is or will be providing. The Q & A in this session gave me and other BIO staff members the chance to hear some of the questions the scientific community has about the Observatory. I followed up this session by attending some great podium presentations about collaborative networks and the Global Lakes Ecological Observatory Network (GLEON).
In the afternoon, I had the chance to talk with more researchers during another meet-and-greet session and visited the BIO booth in the Exhibit Hall. Many thanks to the BIO staff who took the time to speak with ESA attendees about the programs and resources BIO has to offer.
A great day culminated in a Synthesis Center Reception co-hosted by SESYNC, NIMBioS, NCEAS, and the John Wesley Powell Center for Earth System Science Analysis and Synthesis.
Synthesis centers are a signature activity for the Directorate. NCEAS began as an NSF-funded center and paved the way for other NSF-funded centers, including the National Evolutionary Synthesis Center (NESCEnt) at Duke, SESYNC, located in Annapolis, and NIMBioS at the University of Tennessee, which have all been great successes. These centers provide resources and sophisticated infrastructure to allow researchers from varied disciplines to gather together to address new questions that require the synthesis of data.
It was a great day at ESA! I look forward to attending other professional society meetings and conferences throughout my tenure as Assistant Director of BIO.
In 2012, Congress encouraged NSF to create a cross-Foundational activity in Cognitive Science and Neuroscience. Congress recognized that NSF was uniquely positioned to advance research in these areas and NSF responded by developing a cognitive science and neuroscience roadmap outlining our priority areas and potential funding mechanisms.
Then, in Fiscal Year 2013, President Obama announced the multi-agency BRAIN Initiative, with NSF as one of the three lead agencies, along with the National Institutes of Health and DARPA. As a result, the Biological Sciences Directorate—in cooperation with other NSF Directorates (SBE, MPS, CISE, and ENG) —initiated Understanding the Brain, a unique program for fundamental research in neural circuits and neurotechnology, which draws together NSF’s ongoing activities in Cognitive Science and Neuroscience and new BRAIN Initiative activities.
Understanding the Brain aims to generate the tools needed to explore healthy brain function and to establish a comprehensive understanding of how thoughts, memories, and actions emerge from the dynamic activities of the brain. As Congressman Fattah stated at the briefing, “There is so much for us to learn!”
Dr. Scott Thompson, Chair of the Public Education and Communication Committee for the Society for Neuroscience, and Chair of the Department of Physiology at the University of Maryland School of Medicine, agreed with the Congressman that there is an exciting future ahead for neuroscience and he emphasized the value of training and research for undergraduate students.
Another highlight of the event was watching an introduction to the new video series, “Mysteries of the Brain,” co-produced by NSF and NBC Learn. This series eloquently communicates the value and excitement of fundamental brain research and I hope you will find time to watch these terrific videos online.
After the video, we enjoyed three dynamic presentations from scientists at the forefront of brain research. Dr. Gary Lynch from the University of California, Irvine, has uncovered deep connections between learning and memory and his team’s work has played a key role in forming the modern theory of how synapses—the gaps between adjacent nerve cells—encode memory. Dr. Lynch has received multiple grants for basic brain research from the National Science Foundation with potential applications to education and human health. Recently, Dr. Lynch has been using a novel class of drugs in an attempt to reverse the negative effects of aging on the anatomy and physiology of brain cells.
Dr. Spencer Smith joined us from the University of North Carolina, Chapel Hill, where he runs a neuroscience and neuroengineering laboratory. Dr. Smith is working to understand neural circuits to expand our understanding of how the brain processes information. Dr. Smith and his multidisciplinary team of scientists and engineers are developing novel optical systems to create high resolution images of nerve cell activity, for which he and his colleagues received one of the first BRAIN EAGER grants from the National Science Foundation.
Finally, we were privileged to hear from Dr. Aude Oliva from the Massachusetts Institute of Technology. Dr. Oliva has also received support from the National Science Foundation, including a Faculty Early Career Development Program grant for her work categorizing and identifying visual scenes. Dr. Oliva’s work combines state-of-the-art methods in neuroscience, cognitive science, and computer science to discover and model how perception and cognition are realized both in human and in artificial minds.
These three speakers discussed new, key, discoveries about the organ we think of today as more efficient than a 20-Watt ultrahigh performance supercomputer—the brain. They shared new insights about everything from how individual neurons operate to how distant parts of the brain work together, enabling us to learn, see and do almost everything we do. It was so exciting to hear how science is finally unlocking the secrets to how memories are made and retained, and how we are developing new high-tech tools for seeing the brain in action. It was evident some of this research will be the foundation for future treatments for degenerative brain diseases and traumatic brain injuries.
On behalf of the National Science Foundation and the Biological Sciences Directorate, I want to thank everyone involved in this event. It was a great day for science!
The National Academies recently released the report, Enhancing the Effectiveness of Team Science. This report was co-sponsored by the National Science Foundation and Elsevier. The goal of this consensus study was to examine the science of team science, or the collaborative process by which “large and small scientific teams, research centers, and institutes organize, communicate, and conduct research.”1 Some of the outcomes of this study are relevant to the NSF as a funding agency; for example, the study committee recommends that:
Public and private funders foster a culture within the scientific community that supports those who want to undertake team science through:
funding, white papers, training workshops, and other approaches.
Funders should work with the scientific community to:
encourage the development and implementation of new collaborative models (e.g., research networks, consortia),
develop incentives for team science, and
provide resources (e.g., information repositories, training modules).
Funding programs should support research on the effectiveness of science teams and larger groups, which will require community effort (e.g., new topics and new research methods).
The ideas and recommendations in the report led me to consider the role of team science and single-Principal Investigator (PI) science in light of how BIO-funded researchers can contribute to understanding the rules of life. As a neuroscientist, I “grew up” in a world of single-PIs, but the next generation in neuroscience–my postdocs and grad students–are all part of big team science, in part due to the sheer complexity of the problem of understanding the brain. Thinking across biology, however, we see a more diverse picture. Though there are pieces of understanding the rules of life that require a team approach–for instance, when mapping out the wiring diagram of the brain (the connectome)–there are many problems that are beautifully amenable to single-PI science. For example, individual researchers may work toward understanding and enhancing photosynthesis, or sequencing Archaea from deep in the ocean to investigate the evolution of eukaryotic cells. Other projects may be a hybrid state of affairs between single-PI research and team science.
I think that there has always been a healthy balance at NSF between our experience and excellence in running big team science programs, facilities, and centers and our commitment across the Foundation to the Core Programs and single-PI research, and this serves the Foundation well. Some areas of research, like neuroscience, may be existence proofs for the effectiveness of team science; however, it is worth examining the science of team science within the various disciplines and sub-disciplines that contribute to our understanding of the rules of life.
Biology ab initio: Understanding the rules of life
Abstract: The mission of the National Science Foundation’s Directorate for Biological Sciences is to enable discoveries for understanding life. Our theoretical understanding of life is based on first principles; for example, that life comes in dynamic packages (e.g., cells and organisms) and these packages reproduce with variable heredity, expanding in population size until constrained. Among life’s first principles—the constraints, drivers, and feedbacks of evolution—there must be discoverable sets of rules that, once identified, would contribute to new or refined conceptual understandings of life, new approaches to studying life, and new, fundamentally different, questions about life and its origins. There have already been advances in our understanding of some rules, for example, in our knowledge of how protein dynamics contribute to their function and of developmental signaling, but many rule sets remain to be discovered. And such discoveries will be the engine for innovation in other disciplines that make use of biology. Understanding the rules of life is the business of biology in the 21st Century.